Senior Software Engineer - Commercial - #4978

GRAIL · San Francisco

Software EngineeringResearch & DevelopmentHybridFull-Time

GRAIL is hiring a Senior Software Engineer - Commercial - #4978 in San Francisco, California (hybrid, full-time). Posted 13 October 2026. Apply directly on GRAIL's own careers site — no account needed.

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.
 
We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.
 
GRAIL is headquartered in the Bay Area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.
 
For more information, please visit grail.com

GRAIL is seeking a Senior Software Engineer for the Commercial engineering team within our Technology organization. Our team builds and operates the patient- and provider-facing software behind the Galleri® test, including my.grail.com and provider.grail.com, along with the systems that collect and deliver the clinical data the test depends on. The software we write sits directly in the path between a patient ordering a test and a physician acting on the result, so correctness, reliability, and clarity matter as much as velocity.

This is a backend-leaning full-stack role for an engineer who wants meaningful ownership. You will design and build cloud-native services in Go on AWS and Kubernetes, and you will follow your work through to the React interfaces that patients and clinicians actually use. You will own systems end to end — design, implementation, testing, rollout, and production operation — and you will help raise the bar for the engineers around you. If you want your work to have a direct line to earlier cancer detection, this is a rare place to do it.

This role is based in Sunnyvale, California. It offers a flexible work arrangement, with the ability to work from GRAIL's office or from home. Our current flexible work arrangement policy requires that a minimum of 60%, or 24 hours, of your total work week be on-site. Your specific schedule, determined in collaboration with your manager, will align with team and business needs and could exceed the 60% requirement for the site. At our Sunnyvale campus, Tuesdays and Thursdays are the key days where we encourage on-site presence to engage in events and on-site activities.

 

Responsibilities

Required Qualifications

Preferred Qualifications

The expected, full-time, annual base pay scale for this position is $169K- $180K.

At GRAIL, we believe in recognizing and rewarding the contributions our employees make to our mission and success. In addition to base pay, this role may be eligible for additional compensation, including an annual bonus and/or other incentives, in accordance with applicable plans and the company's discretion. The posted range reflects our good-faith estimate of the base pay we expect to offer for this position at the time of hire. Actual compensation will be determined based on factors such as the candidate’s experience, skills, qualifications, and other relevant considerations.

At GRAIL, we invest in the health, well-being, and future of our employees and their families. Employees in this role are eligible for a comprehensive and competitive benefits package designed to support what matters most, including flexible time off or vacation, a 401(k) retirement plan with employer match, medical, dental, and vision coverage, and thoughtfully selected well-being programs. Benefits are offered in accordance with applicable plans and policies.

GRAIL is an equal employment opportunity employer, and we are committed to building a workplace where every individual can thrive, contribute, and grow. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, disability, status as a protected veteran, or any other class or characteristic protected by applicable federal, state, and local laws. Additionally, GRAIL will consider for employment qualified applicants with arrest and conviction records in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities. Please contact us at rc@grailbio.com if you require an accommodation to apply for an open position.

GRAIL maintains a drug-free workplace. We welcome job-seekers from all backgrounds to join us!

Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

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